Implantable Tissue Engineered Brain Pathways

Innervace spun out of the University of Pennsylvania
is a company focused on the development and commercialization
of anatomically inspired living scaffolds for brain pathway reconstruction.

Innervace spun out of the University of Pennsylvania
is a company focused on the development and commercialization
of anatomically inspired living scaffolds for brain pathway reconstruction.

Our lead clinical product is a tissue-engineered nigrostriatal pathway (TE-NSP) that mimics the lost nigrostriatal pathway in patients with Parkinson’s disease (PD). TE-NSPs are microinjected into the brain, with the TE-NSP cell bodies implanted into the substantia nigra and their axonal projections terminating in the striatum. Then the TE-NSPs create synaptic connections within the local architecture, further establishing a biologically relevant network integrated with the existing neuroanatomy.

 

Other PD cell therapies infuse dopaminergic neurons straight into the striatum, potentially creating uncontrolled dopamine release. TE-NSP recapitulate the lost circuitry in PD patients, allowing for refined and controlled dopamine release.

Advantage and Opportunity

Meet the Team. The team are experts in neural tissue
engineering and, brain injury and repair.

Headshoots MASTER
Nader Halim, PhD, MBA
Chief Executive Officer
Dave Greenwald sized 2
Dave Greenwald, PhD
Deerfield Management Company
Board Director
Jonathan Leff sized 2
Jonathan Leff
Deerfield Management Company
Board Director
Althea Stillman
Althea Stillman , PhD
IP Group, Inc.
Board Director
Cullen
D. Kacy Cullen, PhD
Co-Scientific Founder
doug smith
Douglas Smith, MD
Co-Scientific Founder