Implantable Tissue Engineered Brain Pathways

Innervace spun out of the University of Pennsylvania
is a company focused on the development and commercialization
of anatomically inspired living scaffolds for brain pathway reconstruction.

Innervace spun out of the University of Pennsylvania
is a company focused on the development and commercialization
of anatomically inspired living scaffolds for brain pathway reconstruction.

Our lead clinical product is a tissue-engineered nigrostriatal pathway (TE-NSP) that mimics the lost nigrostriatal pathway in patients with Parkinson’s disease (PD). TE-NSPs are microinjected into the brain, with the TE-NSP cell bodies implanted into the substantia nigra and their axonal projections terminating in the striatum. Then the TE-NSPs create synaptic connections within the local architecture, further establishing a biologically relevant network integrated with the existing neuroanatomy.

 

Other PD cell therapies infuse dopaminergic neurons straight into the striatum, potentially creating uncontrolled dopamine release. TE-NSP recapitulate the lost circuitry in PD patients, allowing for refined and controlled dopamine release.

Advantage and Opportunity

Meet the Team. The team are experts in neural tissue
engineering and, brain injury and repair.

Cullen
D. Kacy Cullen, PhD
Co-Founder
doug smith
Douglas Smith, MD
Co-Founder
Headshoots MASTER
Nader Halim, PhD, MBA
Business Development Lead
Kames Harris
James Harris, PhD
Technical Lead
Althea Stillman
Althea Stillman , PhD
Associate Director, Life Sciences, IP Group, Inc.
Director
Bhavana Mohanraj
Bhavana Mohanraj, PhD
Assistant Director, Venture, Penn Center for Innovation
Board Member
Headshoots MASTER
M. Sean Grady, PhD
Professor of Neurosurgery, University of Pennsylvania
Board Member