Implantable Tissue Engineered Brain Pathways
Innervace spun out of the University of Pennsylvania
is a company focused on the development and commercialization
of anatomically inspired living scaffolds for brain pathway reconstruction.
Innervace spun out of the University of Pennsylvania
is a company focused on the development and commercialization
of anatomically inspired living scaffolds for brain pathway reconstruction.
Our lead clinical product is a tissue-engineered nigrostriatal pathway (TE-NSP) that mimics the lost nigrostriatal pathway in patients with Parkinson’s disease (PD). TE-NSPs are microinjected into the brain, with the TE-NSP cell bodies implanted into the substantia nigra and their axonal projections terminating in the striatum. Then the TE-NSPs create synaptic connections within the local architecture, further establishing a biologically relevant network integrated with the existing neuroanatomy.
Other PD cell therapies infuse dopaminergic neurons straight into the striatum, potentially creating uncontrolled dopamine release. TE-NSP recapitulate the lost circuitry in PD patients, allowing for refined and controlled dopamine release.
Advantage and Opportunity
Meet the Team. The team are experts in neural tissue
engineering and, brain injury and repair.
Board Director
Board Director
Board Director
